Group: Bone Physiopathology
Acronym: FPO
Registry number: G20/4-03
School/Centre: MEDICINE
Memberships:
Research thematic areas:
UNESCO Code: 241008, 320714
Keywords:
Skeleton, Bone Metabolism, Osteocytes, Osteoblasts, Osteoclasts, Osteoclasts, Cancer, Diabetes, Ageing, Metastasis
Relevant characteristics of the research group (description of the group's activity): Our line of research focuses on understanding the pathophysiological implications of communication between the different cells in the bone environment. We study the mechanisms of mechanotransduction in bone cells, as well as the activation of membrane receptors, which are key to bone metabolism (PTH1R, among others) and the impact of different pathologies such as diabetes or ageing on these processes. On the other hand, we study the role of communication between bone cells in the tumour microenvironment. We are interested in how factors produced by tumour cells affect the formation of pre-metastatic bone niches and tumour progression. Contact: [email protected]; [email protected]
Our line of research focuses on understanding the pathophysiological implications of communication between the different cells in the bone environment. We study the mechanisms of mechanotransduction in bone cells, as well as the activation of membrane receptors, which are key to bone metabolism (PTH1R, among others) and the impact of different pathologies such as diabetes or ageing on these processes. On the other hand, we study the role of communication between bone cells in the tumour microenvironment. We are interested in how factors produced by tumour cells affect the formation of pre-metastatic bone niches and tumour progression.
Contact: [email protected]; [email protected]