The Spanish Society of Medicinal Chemistry (SEQT) www.seqt.org is pleased to announce the XVIIth National Meeting on "Advances in Drug Discovery: Successes, Trends and Future Challenges", scheduled to be held on October 2-4th in Madrid, Spain.

This event is the most important one in the Spanish Medicinal Chemistry field and is organized biennially in different cities. This year the meeting will be hosted by the Faculty of Pharmacy of CEU San Pablo University and will take place in Madrid City centre (C/ Tutor nº 35), easily accessible from Barajas Airport and from Atocha Rail Station by public transportation.

Accommodation at hotels in the same area will be arranged, so that most of the participants can stay within walking distance of the meeting venue.

The Meeting will cover different topics related to Medicinal Chemistry as the design of drugs, new emerging targets, molecular recognition, chemical biology approaches in drug discovery, epigenetics in medicinal chemistry, predictive tools, diagnostic agents, or labeled ligands employed as pharmacological tools. Oral communications and a poster session will provide the opportunity for all participants to present their current results. To reward high quality contributions, “Best Oral communication and Poster” prize will be delivered at the closing of the Meeting.

Madrid, the capital of Spain is easily reached by air, railway or car from all European countries and October is ideal time to enjoy natural and cultural beauties of the city. We believe that participation XVIIth National Meeting on "Advances in Drug Discovery: Successes, Trends and Future Challenges" in Madrid will be for you an unforgettable scientific and personal experience.

We are looking forward to welcoming you in Madrid!

Beatriz de Pascual-Teresa (Facultad de Farmacia, Universidad CEU San Pablo, Madrid)

Antoni Torrens (Colaboraciones en I+D y Alianzas Estratégicas, Esteve, Barcelona)

Ana Gradillas (Facultad de Farmacia, Universidad CEU San Pablo, Madrid)

Ana Ramos (Facultad de Farmacia, Universidad CEU San Pablo, Madrid)

Mª Fernanda Rey-Stolle (Facultad de Farmacia, Universidad CEU San Pablo, Madrid)

Ana Castro (CSIC: Instituto de Química Médica, Madrid)

Ana San Félix (CSIC: Instituto de Química Médica, Madrid)

José María Zapico (Facultad de Farmacia, Universidad CEU San Pablo, Madrid)

José Mª Zapico
E-mail: xviicongresoseqt@ceu.es
Tel: 913724700 (ext 4723)
Facultad de Farmacia
Universidad CEU San Pablo
Urbanización Montepríncipe
28925 Alcorcón
Madrid (Spain)

Wednesday, October 2nd

13:30 Registration

15:30 OpeningCoral Barbas, Vicechancellor of Research, CEU-USP; Beatriz de Pascual-Teresa, Organizing Committee, CEU-USP; Antoni Torrens, President SEQT

ChairpersonJavier Rojo/Antoni Torrens

16:00 Inaugural Lecture: "Antibody-Based Therapeutics for Cancer Therapy"
Peter Senter, Seattle Genetics, EEUU

17:00 IS1: “Synthetic biology and smart therapeutic systems”
Guillermo de la Cueva Méndez (BIONAD- Centro Andaluz de Nanomedicina y Biotecnología, Málaga, Spain)

17:30 IS2: “Glycofullerenes for Biological Applications”
Nazario Martín León (Universidad Complutense de Madrid, Spain)

18:00 SEQT Awards

18:30 OC1: “A new strategy to gain selectivity within the gelatinases subfamily”
Benjamin Fabre. (Universidad CEU San Pablo, Madrid, Spain) Ramón Madroñero SEQT Award

20:00 Welcome Cocktail

Thursday, October 3rd

MORNING SESSION

Chairperson:
Mª José Camarasa/Mª Luz López

09:00 IS3: “3D Pharmacophore Models: Efficient Tools for Hit Identification,Lead Optimization, and Ligand Profiling”
Thierry Langer (Prestwick Chemical, Illkirch, France)

09:30 IS4: “Integrating Intramolecular Hydrogen Bonding (IMHB) considerations in Drug Discovery using lipophilicity as a Tool”
Giulia Caron (University of Turin, Italy)

10:00 IS5: “Nucleic acids in G-quadruplex conformations as innovative targets against cancer”
Stefano Alcaro (Universitá "Magna Graecia", Catanzaro, Italy)

10:30 Coffee Break

11:00 IS6: “ORL-1 Antagonists: Lead Optimization and PET Tracer Development”
Angeles Martínez Grau (Lilly, S.A., Madrid, Spain)

11:30 IS7: “The asymmetric architecture of G protein-coupled receptor heteromers with G proteins explains signalling cross-talk”
Peter McCormick (Universidad de Barcelona)

12:00 Oral Communications
Communications (OC2-OC5)

OC2: “Synthesis and Pharmacological Evaluation of Acetaminophen Analogues with Antinociceptive Properties”
Pilar Goya (Instituto de Química Médica, CSIC, Madrid, Spain)

OC3: “Synthesis and Pharmacological Evaluation of Acetaminophen Analogues with Antinociceptive Properties”
Pilar Goya (Instituto de Química Médica, CSIC, Madrid, Spain)

OC3:“Applications of click chemistry in sphingolipid research”
Antonio Delgado (IQAC-CSIC, Barcelona, Spain)

OC4:“Computational chemistry for identifying differences among choline kinases active sites”
Lucía Serrán Aguilera (Universidad de Granada, Spain)

OC5:“Impact of fluorination on proteolytic stability of peptides: a case study using α-chymotrypsin and pepsin”
Jeremie Mortier (Free University of Berlin, Germany)

13:00 Lunch

AFTERNOON SESSION

Chairperson: Pilar Goya/Julio Álvarez Builla

15:00 IS8: : “Amino Acid-Derived β–Lactams: Synthesis, Biological Activity and Beyond”
Rosario González Muñiz (Instituto de Química Médica, CSIC, Madrid, Spain)

15:30 OC6: “New non-metathetic processes catalysed by ruthenium complexes for the synthesis of heterocycles”
Javier Pérez-Castells (Universidad CEU San Pablo, Madrid, Spain)

15:45:Poster Session and Coffee

16:45 Oral Communications (OC7-OC8)

OC7: “Merging of pineal neurochemicals. pharmacological profiles and neurogenic potential”
Mario de la Fuente Revenga (Instituto de Química Médica, CSIC, Madrid, Spain)

OC8:“Drugging the von hippel lindau E3 ubiquitin ligase: potential drugs and useful chemical tools”
Carles Galdeano (University of Dundee, Dundee, UK)

19:30 Cultural evening:
"Discover most unknown Madrid`s old town,even for locals; in a 1,30-1,45 hrs aprox walking tour seeing highlights bringing back its ancient past,legends,alleyways,monuments and curiosities with a fully licensed guides that will make you travel through the time" Underground: Puerta del Sol metro station.
 

Friday, October 4th

MORNING SESSION

ChairpersonJordi Gracia/Javier Fernández Gadea

09:00 IS9: “Next-Generation Inhibitors for Kinases, Histone-Deacetylases, and Histone Methyltransferases: The discovery of Slowness”
Gerhard Müller (Mercachem, The Netherlands)

09:30 IS10:“Exploring the kinome with kinase broad screening”
Gary Tresadern (Janssen R&D, Beerse, Belgium)

10:00 IS11“Antibiotic Treatment of Tuberculosis: Old Problems, New Solutions”
Mónica Cacho Izquierdo (GlaxoSmithKline, Madrid, Spain)

10:30 Coffee Break

11:00 Oral Communications (OC9-OC12)

OC9: "Design of mycobacterium tuberculosis shikimate kinase inhibitors inspired by the enzymatic movements for catalytic turnover”
Verónica Prado (CIQUS, Universidad de Santiago de Compostela, Spain)

OC10: “From hit to lead in search of new inhibitors of the enzyme isoprenylcysteine carboxyl methyltransferase (ICMT)”
Silvia Ortega-Gutiérrez (Universidad Complutense, Madrid, Spain)

OC11:“Design, synthesis and biological evaluation of cyclic acylguanidines as bace-1 inhibitors: effect of ring size on activity and selectivity versus BACE-2”
Myriam Ciordia (Janssen Pharmaceutical Research & Development, Toledo, Spain)

OC12: “-Omics tools for studying changes in metabolic pathways of new drugs”
Isidre Masana (Agilent Technologies)

12:00 SEQT Meeting

13:00 Lunch

AFTERNOON SESSION

ChairpersonConcepción González Bello/Antonio Pineda

15:00 IS12:“ETP-CNIO Academic Early Drug Discovery: PIM Kinase Inhibitors”
Joaquín Pastor (CNIO- Centro Nacional de Investigaciones Oncológicas, Madrid, Spain)

15:30 OC13“Different levels of apoptosis caused by enantiomers in breast cancer cells”
Joaquín M. Campos (Universidad de Granada, Spain)

15:45: Poster Session and Coffee

16:45 Oral Communications (OC14-OC16)

OC14:“Tumor vascular disrupting agents: identification and optimization of novel hits”
Mª Dolores Canela (Instituto de Química Médica, CSIC, Madrid, Spain)

OC15:“3-Substituted indole derivatives as antimitotic agents”
Raquel Álvarez Lozano (Universidad de Salamanca, Salamanca, Spain)

OC16:“Chemical biology for drug discovery: two case studies in drug repurposing”
Jordi Quintana (Parc Científic de Barcelona, Spain)

17:30 Concluding Remarks. Poster and Oral Communication Awards

21:00 Gala Dinner
Gala dinner will be held in "La Posada de la Villa”, a classic Spanish restaurant in Madrid. It is included in the distinguished Michelin Guide) and has been awarded in many occasions: Grand Collar Gourmet, the Chaîne des Rotisseurs, etc.

Posada de la Villa Restaurant C/ Cava Baja, 9. Underground: La Latina metro station. 

Important information about posters:

• Poster session 1: Thursday October 3rd 15:45-16:45: ODD numbers
• Poster session 1: Friday October 4th 15:45-16:45: EVEN numbers

Antibody-Based Therapeutics for Cancer Therapy

Dr. Peter SENTER

(SEATTLE GENETICS, EEUU)

Dr. Peter Senter. PhD in Chemistry from the University of Illinois followed by postdoctoral research at the Max-Planck Institute in Göttingen, Germany. He joined Seattle Genetics in 1998 and has served as Vice President, Chemistry since September 2002. Dr. Senter is responsible for research programs covering antibody-drug conjugates, anticancer prodrugs, and protein engineering. Before joining Seattle Genetics, he held positions at Cytokine Networks, Bristol Myers Squibb Pharmaceutical Research Institute, and the Dana Farber Cancer Institute. Dr. Senter is an Affiliate Professor in Bioengineering at the University of Washington and is the Senior Editor of Bioconjugate Chemistry, an ACS journal. He has authored more than 130 scientific publications and holds more than 40 patents.

Amino Acid-Derived β–Lactams: Synthesis, Biological Activity and Beyond

Dr. Rosario GONZÁLEZ-MUÑIZ

(IQM-CSIC, Madrid, Spain)

Dr. Rosario González-Muñiz, Ph.D. in chemistry from Madrid Autónoma University, and post-doctoral stay at René Descartes University (Paris V). She is scientific researcher at the Medicinal Chemistry Institute (IQM-CSIC), where she was the Deputy Director (2005-2011). Specialist in peptides, peptidomimetics and bioactive small-molecules, her recent research interests include the design and synthesis of new modulators of protein-protein interactions and different types of ion channels.

3D Pharmacophore Models: Efficient Tools for Hit Identification,Lead Optimization, and Ligand Profiling

Dr. Thierry LANGER

(PRESTWICK CHEMICAL, Illkirch, France)

Dr. Thierry Langer, CEO and President of Prestwick Chemical, is a well known scientist in the drug discovery field. Former Professor of pharmaceutical chemistry at Innsbruck University (Austria), and co-founder of the software company Inte:Ligand GmbH (Vienna, Austria), he is author of more than 160 original papers in the field of computational medicinal chemistry.

Integrating Intramolecular Hydrogen Bonding (IMHB) considerations in Drug Discovery using lipophilicity as a Tool

Dr. Giulia CARON

(UNIVERSITY OF TURIN, Turin, Italy)

Dr. Giulia Caron is assistant professor at University of Turin. She has a broad experience in the design, synthesis and phisycochemical characterization of biologically active molecules. Her recent research is focused on in silico techniques, applying QSAR and ADMET predictions in drug design and related areas. She is coauthor of more than 50 publications.

More details at www.casmedchem.unito.it

Nucleic acids in G-quadruplex conformations as innovative targets against cancer

Dr. Stefano ALCARO

(UNIVERSITÁ "MAGNA GRAECIA", Catanzaro, Italy)

Stefano Alcaro is full professor of Medicinal Chemistry affiliated at the Dipartimento di Scienze della Salute, Università Magna Graecia di Catanzaro (Italy). He uses innovative computational techniques in rational drug discovery projects against anticancer targets (PTPRJ, DNA duplex and G-quadruplex) and other enzymes (HIV-1 RT, COX 1/2 and MAO A/B). He is co-author of about 110 publications.

Glycofullerenes for Biological Applications

Dr. Nazario MARTÍN LEÓN

(UNIVERSIDAD COMPLUTENSE DE MADRID, Madrid, Spain)

Dr. Nazario Martín is full professor at the UCM. His research interests span a range of targets with emphasis on the chemistry of fullerenes, carbon nanotubes, graphenes, π-conjugated systems as molecular wires, and electroactive molecules. He has been the recipient of the “Dupont Prize of Science” in 2007, the “Gold Medal and Research Award” by the Spanish Royal Society of Chemistry in 2012, the national “Jaime I Award for basic research” 2012, the “EuCheMS Lecture Award” in 2012, and more recently the “Alexander von Humboldt Award” .

ORL-1 Antagonists: Lead Optimization and PET Tracer Development

Dr. Angeles MARTÍNEZ GRAU

(LILLY, S.A., Madrid, Spain)

Dr. María Angeles Martínez Grau. Senior Research Advisor at Eli Lilly. PhD in Organic Chemistry by the UCM, she recieved the National Prize for Young Scientists (1995). After a postdoctoral stay at University of Pittsburgh, she joined Lilly in 1998. She has held different positions in the company, both in Madrid and Indianapolis, and has contributed to the delivery of 8 clinical candidates in the areas of Neuroscience, Obesity and Diabetes. She currently leads a group of 11 Medicinal Chemistry scientists working in Diabetes projects.

Synthetic biology and smart therapeutic systems

Dr. Guillermo de la CUEVA

(BIONAD- Centro Andaluz de Nanomedicina y Biotecnología, Málaga, Spain)

Dr. Guillermo de la Cueva Méndez is currently responsible and group leader of the Area of Therapeutic Nanosystems at the Centro Andaluz de Nanomedicina y Biotecnología (BIONAND). His research group is focused on the development of intelligent biological drugs and therapeutic nanosystems by means of Synthetic Biology. He graduated in Biochemistry and Molecular Biology at the UAM and obtained the PhD at CIB-CSIC. After a postdoctoral stay at the Wellcome/Cancer Research Campaign Institute (Cambridge, UK), he joined the Hutchison/MRC Research Centre (Cambridge, UK) as Principal Investigator, until his recent incorporation to BIONAD.

Next-Generation Inhibitors for Kinases, Histone-Deacetylases, and Histone Methyltransferases: The discovery of Slowness

Dr. Gerhard MÜLLER

(MERCACHEM, The Netherlands)

Dr. Gerhard Müller is Senior Vice President Medicinal Chemistry at Mercachem. PhD in Organic Chemistry by the Technical University of Munich, he has worked in different pharmaceutical companies, and on a wide range of target classes from numerous disease areas, always emphasizing target family-centric medicinal chemistry approaches. Over the last 10 years he specialized in kinase inhibitor research establishing novel design paradigms, proven by numerous publications.

Antibiotic Treatment of Tuberculosis: Old Problems, New Solutions

Dr. Mónica CACHO IZQUIERDO

(GLAXOSMITHKLINE, Madrid, Spain)

Dr. Mónica Cacho Izquierdo is Principal Scientist at TB DPU, Tres Cantos Medicines Development Center, GlaxoSmithKline. PhD in Organic Chemistry by the Universidad of San Pablo CEU (USP-CEU). After a post-doctoral stay at the University of Nottingham, she joined the USP-CEU as Profesor Colaborador. Later she moved to Noscira S.A., then to the Instituto de Química Médica (CSIC) and finally to GSK. Her research work covers several diseases (cancer, AIDS, Alzheimer) and targets (DNA topoisomerase, CDK-1, adrenomomedullin, reverse transcriptase). Currently her work is focused on the discovery of new anti-tuberculars.

ETP-CNIO Academic Early Drug Discovery: PIM Kinase Inhibitors

Dr. Joaquín PASTOR

(CNIO- Centro Nacional de Investigaciones Oncológicas, Madrid, Spain)

Dr. Joaquín Pastor, Ph.D. in Chemistry by the University of Alcalá de Henares (UAH). Postdoctoral stage (1994-1998) at The Scripps Research Institute (Prof. K.C. Nicolaou group). Back in Spain, he joined Janssen (J&J PRD) as head of the HTMC group and acting as team leader in different projects/therapeutic areas such as CNS, metabolic disorders and oncology, collaborating in the progression of compounds to NME stage. In 2008 he joined CNIO, and since 2011 he is Director of the Programme leading the drug discovery activities of the CNIO. He is author and co-author of more than 70 scientific publications and patents in the field of drug discovery.

The asymmetric architecture of G protein-coupled receptor heteromers with G proteins explains signalling cross-talk

Dr. Peter J. McCORMICK

(UNIVERSITY OF BARCELONA, Barcelona, Spain)

Dr. Peter J. McCormick. Bachelors in Science from Washington University in St. Louis. PhD in Biochemistry from Texas A&M University followed by postdoctoral research at the National Institutes of Health in Bethesda, Maryland, USA. He obtained a Ramon y Cajal in 2009 and moved to the University of Barcelona where he is a group leader in the Molecular Neurobiology group. His work involves the identification and understanding of G-protein coupled receptor heterodimers.

Exploring the kinome with kinase broad screening

Dr. Gary TRESADERN

(JANSSEN R&D, Beerse, Belgium)

Dr. Gary Tresadern currently heads the Molecular Informatics (MI) group at Janssen R&D in Belgium . Gary joined Janssen in 2005 as a computational chemist and molecular modeller and has contributed to multiple discovery projects reaching clinical evaluation. He has a particular interest in hit and lead generation, GPCRs, Kinases, and virtual screening. He graduated with a PhD in computational chemistry from the University of Manchester in 2003 and worked in the UK for Tripos Discovery Research from 2002 to 2005. He is co-author of 24 scientific articles, 2 book-chapters and co-inventor on 13 published patent applications.

Key Dates

Registration opening date: May, 2013

Deadline Abstract submission: September 6th, 2013

Notification of abstract acceptance/rejection: middle of September , 2013

Meeting venue

The XVII SEQT National Meeting will be hosted by the Pharmacy Faculty of CEU San Pablo University: C/ Tutor 35, 2800 8 Madrid.

Means of arrival at the venue

By Underground

Lines 3, 4 and 5 (Argüelles station) of Madrid Underground: METRO DE MADRID

By Bus

Bus 1

Bus 44

Bus 133

EMT MADRID

Click here for How to reach the Meeting Venue (calle Tutor nº 35) from the airport

Suggested Hotels

The suggested hotels for XVII SEQT National Meeting 2013 are located near the meeting venue or at walking distance and are easily accessible by Metro from Barajas airport or from Atocha Rail station. The rates listed are per night and include breakfast and 10% VAT.

Click on the names to get more information about each hotel.

Booking requests should be made directly to your preferred hotel via the online booking form or via e-mail. Please, indicate your attendance to the meeting.
Direct payment must be made by the customer at the hotel when booking.
These prices will remain in effect until September.

About Madrid

Madrid is the capital and largest city of Spain. Madrid is considered one of the top European destinations concerning art museums. The museums Del Prado, Reina Sofia or Thyssen have some of the most fantastic collections of famous Spanish painters like Velazquez, Goya, Picasso or Miro. Madrid possesses a wealth of cultural attractions; it is full of great monuments, like the Royal Palace, the Plaza Mayor or the many statues all around the city.

If you like to be entertained, Madrid has two big amusements parks, the Parque de Atracciones and the Warner Bros Park and there are regular international concerts, big flea markets, parades and other activities going on.

Madrid is passionate about sport. Whether you want to enjoy a major sporting event or practise a particular sport, you will be spoilt for choice.

Madrid is also a thrilling city with hundreds of theatre shows, opera, dancing and countless other forms of nightlife.

Visit http://www.esmadrid.com/en/portal.do for further details.

Curso de Certificación Internacional en Cineantropometria - ISAK Nivel I

La cineantropometría es el área de la ciencia encargada en la medición de la composición del cuerpo humano. Los cambios en los estilos de vida, la nutrición, los niveles de actividad física y la composición étnica de las poblaciones, provocan cambios en las dimensiones corporales. Tomando la medida del cuerpo humano y determinando su capacidad para la función y el movimiento en una amplia serie de ámbitos, la cineantropometría es la unión entre la anatomía y el movimiento.

Curso destinado a

Estudiantes y Profesionales en: Nutrición Humana y Dietética; Ciencias de la Actividad Física y el Deporte, Medicina, Fisioterapia, Enfermería; Antropología, Ergonomía, etc.

Objetivos

• Conocer la historia, evolución y desarrollo de la Cineantropometría a nivel nacional e internacional.
• Conocer las diferentes aplicaciones de la Cineantropometría.
• Dominar la técnica de medición de las diferentes variables antropométricas con el perfil restringido (nivel 1)
• Formar antropometristas que trabajen con calidad, precisión y de una manera estandarizada.

Contenidos

• Teóricos
  • Historia de ISAK. Esquema Acreditación Internacional ISAK.
  • Composición corporal
  • Proxemia y ética.
  • Instrumentos: manejo y calibración del equipo.
  • Puntos antropométricos perfil restringido (nivel 1)
  • Toma medidas antropométricas del perfil restringido (nivel 1)
  • Error técnico de medida.
• Prácticos
  • Manejo del equipo antropométrico (calibre de pliegues cutáneos, cinta antropométrica y paquímetro).
  • Marcaje de puntos de referencia antropométricos del perfil restringido.
  • Metodología para la toma de medidas

Evaluación

Al finalizar el curso se debe superar un examen práctico y teórico, donde los candidatos demuestran su nivel de conocimientos, precisión y exactitud (error intra- personal e inter-evaluador).

Una vez finalizado el curso los candidatos deben completar 20 perfiles antropométricos (medir a 20 personas) y entregar los resultados al director del curso, en un plazo de 4 meses desde la conclusión del curso. Si la precisión es satisfactoria, se les otorgará la Certificación ISAK, válida por 4 años y 4 meses.

Requisitos para el curso

• Acudir con ropa cómoda, tipo deportiva, pantalón corto o bañador (corto también), camiseta amplia. Bikini o top si son mujeres.
• Calzado tipo baño.
• Los alumnos participarán como modelos durante el curso, exceptuando en el examen.
• Se recomienda acudir con portátil y un pendrive para recoger la documentación del curso.

Requisitos para obtención de la certificación ISAK

• Asistencia del 100% al curso.
• Aprobar con calificación mínima de 80 % en los dos exámenes teórico y práctico a celebrar el último día del curso. Los resultados de esta evaluación se darán el mismo día del examen.
• Realizar la medición de 20 perfiles antropométricos completos en los plazos establecidos (nivel 1: 4 meses; nivel 2: 6 meses) desde la conclusión del curso.

Directora del curso

Dra. Ángela García González

Profesora Adjunta Departamento de Ciencias Farmacéuticas y de la Salud (Universidad CEU-San Pablo). Antropometrista nivel 3-ISAK. Miembro del Grupo Español en Cineantropometría.

Profesorado

• Dra. Natalia Úbeda Martín. Profesora Titular Departamento de Ciencias Farmacéuticas y de la Salud (Universidad CEU-San Pablo). Antropometrista nivel 2-ISAK
• Dra. Teresa Partearroyo Cediel Profesora Colaboradora Doctora Departamento de Ciencias Farmacéuticas y de la Salud (Universidad CEU-San Pablo). Antropometrista nivel 2-ISAK

Lugar de Celebración

Facultad de Farmacia Universidad CEU-San Pablo-Madrid Urb Montepríncipe, Av Montepríncipe s/n 28925 Alcorcón 28925 Alcorcón Madrid, España Telf. 91.372.47.00

Cómo llegar

Autobuses 571, 573, 574

Metro Ligero L3 (Montepríncipe)

Fechas y Horario

9 de mayo 2014 15:00-20:00
10 de mayo 2014 9:00-20:00
11 de mayo 2014 9:00-14:00