Investigación
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Investigación

METABOLOMA OSCURO EN APLICACIONES CLÍNICAS

Grupo: METABOLOMA OSCURO EN APLICACIONES CLÍNICAS

Acrónimo: DARKMET

Número de registro: G25/5-20

Facultad/centro de adscripción: Facultad de Farmacia

Miembros del grupo:

  • Víctor González Ruiz (Investigador Principal)
  • Miguel Fernández García
  • Cristina Muñoz San Martín
  • Luz Alonso Dasques
  • Isabel Fernández Prades

Áreas temáticas de investigación:

 

  • DESARROLLO DE NUEVAS TÉCNICAS DE PREPARACIÓN DE MUESTRA, SEPARACIÓN E IONIZACIÓN PARA METABOLÓMICA
  • USO DE METABOLÓMICA EN DIAGNÓSTICO NO INVASIVO DE SUB- E INFERTILIDAD HUMANA Y ANIMAL
  • DESARROLLO DE NUEVAS ESTRATEGIAS DE TRATAMIENTO DE DATOS PARA MATRICES HIPERDIMENSIONALES

Código UNESCO: 2301.10, 2301.03, 2302.19, 3104.11, 2414.03, 2411.16

Palabras Clave:

metabolómica, espectrometría de masas, cromatografía de líquidos, electroforesis capilar, fertilidad humana, reproducción animal, enfermedades infecciosas

Características relevantes del grupo de investigación (descripción de la actividad del grupo):

Integrated into CEMBIO (Center for Metabolomics and Bioanalysis) at CEU San Pablo University, our research group is dedicated to advancing the field of metabolomics and its biomedical applications. We specialize in untargeted and targeted metabolomics using high-resolution mass spectrometry (CE-, GC-, and LC-MS) to profile the small-molecule composition of complex biological samples. Our work aims to uncover metabolic signatures that offer insight into disease mechanisms, diagnostic biomarkers, and therapeutic targets.

 

We are particularly interested in exploring the “dark metabolome”: the vast proportion of metabolites or metabolic signals that remain unidentified or poorly characterized. Our group develops and applies novel sample preparation and analytical resources which, combined with advanced computational strategies, aim to broaden the coverage and improve the reliability of metabolomic readouts, particularly in complex matrices such as reproductive fluids.

 

A central focus of our research is the study of fertility problems in humans and animals, multifactorial conditions that are still underexplored at the molecular level. By integrating metabolomic profiles with clinical and other biological data, we seek to identify specific metabolic alterations in biological fluids that can support improved diagnosis and personalized treatment strategies.

 

Through various national and international collaborations, we are also involved in research addressing other clinical challenges, including HPV and invasive aspergillosis infections, testicular cancer, and additional conditions in which metabolic profiling offers diagnostic or prognostic value. Our interdisciplinary expertise enables us to address complex analytical problems in a clinically meaningful and translationally relevant way.

Contacto: [email protected]